Senior Director/Director, FP&A and R&D Finance

TypeOnsite

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance.

We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

We are seeking a Senior Director/Director to lead the R&D Finance function, which serves as the primary finance business partner to R&D leadership within our Finance organization. The role oversees a hybrid finance and accounting team responsible for accruals, internal reporting, budgeting and forecasting, and strategic financial support across our Research, Technical Operations, and Development organizations.This is a high-impact leadership role that combines a strong understanding of US GAAP accounting with forward-looking FP&A capabilities and a strategic mindset to drive financial performance management and decision support across R&D.

The role will partner closely with Finance leadership, including the Controller and the Director of FP&A and Commercial Finance, as well as with leaders across the R&D organization. The role will be expected to build and scale the R&D Finance team as Immunome’s pipeline grows and matures.

Responsibilities

R&D Financial Leadership & Business Partnership

Lead the R&D Finance function, serving as the primary finance business partner to R&D leadership across Research, Technical Operations, and Development.
Define and execute an effective R&D Finance partnership model that supports financial insight, decision-making, and performance management.
Oversee preparation of internal R&D financial reporting, including variance analysis, budget-to-actuals for cash burn and GAAP activity, and executive-level summaries.
Develop a deep understanding of the activities, timelines, and cost drivers underlying drug discovery, clinical development, and technical operations in order to deliver clear financial analysis and support executive-level decision making.

Budgeting, Forecasting & Strategic Planning

Lead R&D budgeting, forecasting, and long-range planning in partnership with Project Management and R&D leadership.
Develop and maintain detailed program-level and functional forecasts, including robust clinical trial forecasts based on timelines, enrollment assumptions, and cost drivers.
Ensure R&D plans are translated into accurate, forward-looking financial forecasts that support decision-making, scenario analysis, and alignment with enterprise financial objectives.

R&D Accounting & Accruals

Lead monthly accrual tracking and review for significant R&D spend areas, including clinical trials, CROs, and other program-level expenses, as needed.
Review and approve key monthly journal entries related to R&D spend, ensuring compliance with US GAAP and internal accounting policies.
Partner closely with Accounting to ensure timely, accurate close processes and adherence to SOX controls.
Support external reporting and audit activities by providing documentation, analysis, and commentary related to R&D and clinical trial spend.

Team Leadership & Cross-Functional Collaboration

Build, lead, and develop the R&D Finance team, establishing clear roles, expectations, and development plans as the organization and pipeline scale.
Collaborate cross-functionally with Finance and R&D leadership to ensure alignment across financial planning, reporting, accruals, and performance management.
Serve as a key finance participant in cross-functional initiatives to build scalable processes, systems, and infrastructure as the company grows and matures.
Drive cross-functional alignment around assumptions, timelines, and financial implications for R&D programs to ensure consistent planning and communication.

Qualifications

Bachelor’s degree in Finance, Accounting, or related field; CPA and/or MBA preferred.
A minimum of 10 years of progressive experience in finance and/or accounting roles, with significant experience supporting R&D organizations in the life sciences or biotechnology industry.

Knowledge and Skills

Demonstrated experience leading finance activities that integrate financial planning, analysis and reporting, accounting oversight, and effective business partnership in a dynamic and growing organization.
Strong understanding of US GAAP as it relates to R&D accounting, accruals, and complex vendor and clinical trial contracts.
Ability to understand, evaluate, and report on financial information using both GAAP and cash accounting methodologies
Strong business partnering skills with the ability to effectively collaborate with and influence stakeholders across all levels of the organization and a wide range of functional areas.
Proven leadership skills with experience managing small teams, multiple stakeholders, and leading cross-functional initiatives.
Ability to develop a deep understanding of scientific, clinical, and technical drivers across the R&D lifecycle and translate them into clear financial insights.
Excellent communication and presentation skills, with the ability to convey complex financial information to senior management.
Self-directed leader who thrives in a fast-paced, evolving environment and can balance strategic thinking with strong execution and attention to detail.
Proficiency with financial planning/reporting software and ERP systems; Experience with NetSuite, Vena, and working with data from clinical trial planning and management systems is a plus

Washington State Pay Range$211,105 - $303,020USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).