Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.
To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.As the Director, Commercial Assessments, you will play a pivotal role in shaping Madrigal’s long-term growth by evaluating external opportunities beyond the current portfolio, with the focus on MASH and potential adjacenciesYou will integrate scientific understanding, market analytics, and commercial strategy to assess opportunity attractiveness, inform investment decisions, and inform portfolio direction. This position requires strong analytical capabilities, the ability to interpret complex secondary data, and a solid grounding in the science underpinning liver and metabolic diseases.The ideal candidate will have a PhD, MBA or advanced scientific degree , coupled with experience in consulting, forecasting, market research, and business development.
This role reports to the Senior Director of Commercial Strategy & Operations, supporting the Chief Business Officer and SVP, of Global Commercial Strategy & Operations.
Key Responsibilities
- Opportunity Assessment: Lead commercial and strategic evaluations of external assets, indications, and adjacencies relevant to Madrigal’s therapeutic focus
- Market Analytics: Conduct secondary analytics to quantify market size, patient populations, competitive landscapes, and potential revenue opportunities
- Scientific Integration: Leverage deep scientific and clinical understanding to contextualize market findings and strengthen opportunity evaluations
- Due Diligence Support: Partner on due diligence efforts for potential partnerships, collaborations, and in-licensing opportunities.
- Market Research Leadership: Design and manage both primary and secondary market research to validate assumptions and assess opportunity attractiveness
- Forecasting & Valuation: Develop and refine forecasting models, scenario analyses, and valuation frameworks to support portfolio prioritization and BD decisions
- Strategic Insights: Translate complex data into concise, actionable insights for senior leadership and Board-level discussions
- Cross-Functional Collaboration: Work closely with R&D, Finance, Medical Affairs, and Commercial to align scientific and commercial perspectives
- Competitive Intelligence: Maintain a strong understanding of industry trends, emerging mechanisms, and key players across MASH and related metabolic disease areas
- Analytical Tool Development: Establish analytical tools and structured approaches to enhance rigor and consistency in commercial assessment processes
Requirements
Education:
- Advanced scientific degree (PhD, MBA, PharmD, MD or advanced science degree) preferred
- 12-15 years of professional experience
- Background in biopharma, management consulting, or corporate/business development with significant exposure to commercial analytics, forecasting, and opportunity assessment
- Experience working across MASH / Liver, metabolic, cardiovascular, or related therapeutic areas strongly preferred
- Global or cross-regional experience desirable
- Advanced proficiency in Excel, PowerPoint, and data visualization tools (e.g., Tableau)
- Expertise in secondary data sources such as IQVIA, Evaluate, GlobalData, and epidemiological datasets
- Ability to integrate large data sets into actionable insights through structured analysis
Core Competencies:
- Strong analytical and problem-solving skills with consulting-level rigor
- Deep scientific and clinical literacy in metabolic and liver disease mechanisms
- Excellent communication and storytelling skills for senior leadership audiences
- Proven ability to manage multiple high-priority projects with tight timelines
- Demonstrated cross-functional leadership and collaboration across commercial and scientific teams
- Experience in vendor management and external research partnerships
- Background in business development or due diligence a strong plus
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $210,000 - $257,000 per year. We comply with all applicable minimum wage laws.All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create.
By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.
In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need.
Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites.
These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners.
We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.
