Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Job Summary:
Madrigal Pharmaceuticals is seeking a results-oriented Director of Project Management to oversee the planning, resourcing, and execution of R&D programs and cross-functional initiatives. Covering the full product lifecycle – from early development to post-marketing requirements – the Director will partner closely with clinical and functional leaders to build and maintain integrated project plans and ensure delivery on time and within scope. Reporting to the Vice President of Project and Portfolio Management (PPM), this role will be instrumental in driving operational excellence, advancing key milestones, and supporting the success of Madrigal’s development programs.
Position Specific Responsibilities:
- Drive Project Planning: Lead development and maintenance of detailed integrated project plans for multiple R&D programs, studies, and/or projects, ensuring alignment with overall Corporate objectives
- Ensure Project Delivery: Manage project timelines, deliverables, and budgets, proactively identifying and resolving risks or delays, escalating when appropriate
- Influence Optimal Resourcing: Partner with functional leaders to anticipate resource needs, resolve gaps, and ensure effective allocation of talent and capabilities within project scope
- Coordinate Functional Contributions: Partner closely with clinical, regulatory, CMC, and other functional leads to ensure their workstreams are aligned
- Enable Strategic Decision-Making: Provide insights and scenario analyses that inform trade-offs, prioritization, investment decisions within project teams
- Facilitate Team Operations: Serve as the central operational lead for assigned project teams – setting agendas, tracking actions, and ensuring effective communication yielding results
- Implement Best Practices: Promote project management standards, tools, dashboards, and processes that drive efficiency and continuous improvement within project teams
- Support Portfolio Review and Governance: Contribute operational support and content to project and portfolio reviews, governance bodies, and other forums as required
- Mentor and Guide Teams: Serve as a trusted thought partner to project teams, providing hands-on coaching, structure, and accountability within the project management disciple
- Support R&D Initiatives: Partner with VP, PPM on cross-department initiatives, contributing project management and operational support as needed
Specialized Knowledge & Skills:
- Demonstrated success in managing complex, cross-functional drug development program teams
- Understanding of drug development process from discovery through commercialization
- Proficiency with project management software (e.g., SmartSheet, MS Project, etc.)
- Strong ability to synthesize, distill, and succinctly communicate strategy, plan, and status for multiple complex, cross-functional programs to all audiences
- Experience in operating model, governance, and process design and implementation within R&D environments
- Excellent organizational and interpersonal skills, with a track record of leading and influencing cross-functional teams
- Outstanding written and verbal communication skills
- Self-motivated and able to multi-task within a fast-paced environment
- Comfortable with and skilled at navigating ambiguity
- Ability to lead and influence without authority
- Experience working in both small biotech and larger pharmaceutical company environments preferred
- Experience in metabolic or rare disease therapeutic areas preferred
Requirements:
- Bachelor’s degree in scientific or relevant business discipline required. Applicable advanced degree (e.g., MA, MBA, PhD, MD) a plus.
- 3 days per week in office in Conshohocken, PA
Experience:
- 12+ years of relevant experience including a minimum 10 years project management experience
Compensation:
Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source.
Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates.
Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners.
We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.
