Description
Headquarters Location:
South San Francisco, CA
Candidate Location:
Hybrid
Travel Required:
up to 5%
Reports To:
Vice President, Protein Sciences and Early CMC
Department:
Protein Sciences and Early CMC
Position Type:
Full-time
About CytomX Therapeutics:
CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards.
CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engaging bispecific antibodies (“TCBs”), and immune modulators such as cytokines and checkpoint inhibitors (“CPIs”). Learn more at www.cytomX.com.
Who You Are and What You’ll Do:
You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. We are seeking a highly collaborative team player who has experience in high quality protein production and purification to support discovery programs and clinical candidate selection. The successful candidate will work as a Scientist II in the Protein Sciences & Early CMC Department and contribute by managing the cell culture group to produce various therapeutic protein candidates to facilitate the clinical candidate selection process by implementation of innovative production and purification strategies.
Job Responsibilities:
- Collaborate with Research, protein engineering and pharmacology to provide therapeutic and reagent protein candidates of appropriate quality for use in in vitro and in vivo studies.
- Implement innovative mammalian cell culture strategies to improve production of Probodies, bispecific antibodies and cytokine molecules.
- Implement strategies to generate CHO stable pools for lead panels of Probodies, ProTCBs and Procytokines.
- Evaluate alternative CHO cells for the manufacturing of Probody molecules.
- Integrate strategies to improve small-scale protein production and purification.
- Collaborate with protein engineering group in the design of discovery pipeline molecules.
- Solve protein production problems based on scientific principles, current technologies, and personal experience.
- Participate in cross-functional discovery support teams and effectively communicate information to appropriate groups and protein sciences staff.
- Develop cell-based potency assays for lead therapeutic molecules to support CMC analytical method development.
- Manage Direct reports by mentoring and providing career development opportunities.
- Organize data and communicate results in internal and external scientific meetings.
Minimum Qualifications:
- Ph.D. in Biochemistry or Protein Chemistry or related discipline with 3+ years of experience in the biotechnology or biopharma industry or BS/MS in Biochemistry with 12-14 years of experience in the biotechnology or biopharma industry
Preferred Qualifications:
- Expertise in mammalian cell culture is required.
- Expertise in DNA sequence analysis is required
- Expertise in protein/antibody production by transient transfection and stable cell generation is required.
- Experience in molecular cloning, antibody sequencing, is required.
- Experience in the production and purification of antibodies and bispecific molecules in various formats is required.
- Expertise in operating the AKTA systems and Tecan liquid handler is required.
- Should be well versed in therapeutic antibody protein characterization assays including affinity measurements by Octet or Biacore
- Familiarity with monoclonal antibody generation process is desired
- Hands-on experience in operating the HPLC, Bioanalyzer, CE-SDS and iCIEF instruments is desired.
- Demonstrate a commitment to CytomX values of Integrity, Commitment, Creativity, Teamwork, Accountability, and Fun
- Energetic, resourceful self-starter with high integrity
- Intellectually curious, enthusiastic, creative
- Adaptable and resilient with a problem-solving orientation
- Innovative
- Team-player comfortable in fast-moving, dynamic environments
- Excellent leadership and influencing skills
How You Will Work:
- Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
- Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
- Exhibits strong interpersonalskills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
- Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
- Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
- Demonstrates ability and commitment to building effective teams. Attracts, develops, and retains diverse top talent. Aligns, mobilizes, and engages others to achieve and sustain peak performance.
- Has a track record of driving vision and purpose in teams.
Compensation, Benefits, and So Much More
- The expected salary range for this role based on the primary location for this position in California is $140,000.00 - $170,000.00 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
- A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
- A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
- A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.
Conditions of Employment
- Background investigations are required for all positions at CytomX, consistent with applicable law.
CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)
CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.Further, we are committed to the full inclusion of all qualified individuals.
As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [email protected]
Notice to Recruiters/Staffing Agencies
Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited.Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees.
For more information, please contact our HR team at [email protected]Please review our
Applicant Personal Information Processing Notice
to understand what types of personal information we collect from job applicants and why we process such information.
