At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets.
As Director of Medicinal Chemistry, you will work closely with the leadership team to define Lyterian’s chemistry strategy and build internal and external chemistry capabilities. You will leverage your extensive small molecule drug discovery experience to advance Lyterian’s internal pipeline toward the clinic. We look for teammates who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek candidates who are self-motivated, collaborative, proactive, and possess a strong desire to discover novel biology and new drugs.
Efficient time management, excellent organizational and communication skills, and passion for high-quality, translational science are essential.
Impact You'll Make:
- Drive the design and develop small molecule compounds, libraries, and probes based on rigorous data analysis and sound hypothesis
- Oversee the synthesis of small molecules, libraries, and probes
- Manage compound scale-up
- Oversee and manage CRO chemists
- Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications,
- Stay up-to-date with emerging scientific literature
- Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals
Qualifications:
- PhD in synthetic organic chemistry with 12+ years of industry experience in drug discovery
- Deep expertise in small molecule medicinal chemistry (structure-based and property-based drug design, synthetic organic chemistry, ADME/DMPK optimization)
- Track record of advancing small molecule medicinal chemistry programs leading to clinical candidates
- Experience with compound scale-up and IND enabling studies
- Experience with management of medicinal chemist(s), multi-disciplinary research teams, CROs and CMOs with ability to inspire all the above to give their best
- Understanding and utilization of computer aided drug design (CADD)
- Initiative and boldness to dive into a fast-paced new startup
$210,000 - $240,000 a yearThe expected base salary range for this role is $210,000 - $240,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws.
Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.Apply for this job
