About Arda
Traditional pharmaceuticals modulate individual proteins and signaling pathways, aiming to restore tissue and organ function. However, stagnating drug approval rates and incremental efficacy improvements reveal the limits of this approach; the low-hanging fruit has been picked. Arda Therapeutics offers a groundbreaking alternative: targeting cells, not pathways.Our unique strategy focuses on removing the pathogenic cells responsible for chronic diseases such as fibrosis and inflammation. By employing a sophisticated single-cell-based discovery engine, Arda identifies these cells and their surface markers with unprecedented precision.
Our targeted biologics eliminate only the harmful cells, preserving healthy tissue and offering substantially greater efficacy than modulating individual protein targets.At Arda, we combine advanced computational biology, extensive drug development expertise, and deep knowledge of non-oncology cell depletion. With multiple therapeutic programs in development and plans for further expansion, Arda is not just developing treatments; we are transforming the future of medicine.
The Role
As a Scientist or Senior Scientist in Arda’s Protein Science group, you will design, characterize, and optimize cell-depleting biologics to accelerate our therapeutic programs. You’ll evaluate biochemical, biophysical, and cellular properties across formats including monoclonal antibodies, antibody-drug conjugates, and multispecifics. In close collaboration with in vivo and in vitro pharmacology teams, you’ll guide antibody optimization and candidate selection across a range of targets and cell types.This is a high-impact role with the opportunity to shape program direction and advance novel therapies.
In addition to competitive compensation, equity, and comprehensive benefits, we offer a flexible time-off policy and a collaborative, inclusive environment committed to scientific excellence.
In this role, you will:
- Generate, engineer, and characterize biologics against disease-relevant targets
- Interpret biochemical, biophysical, and cell-based data to guide lead optimization and candidate nomination
- Design, execute, and document experiments with rigor and clarity; maintain high-quality ELNs and communicate findings internally
- Develop and optimize assays to assess binding, potency, and stability (e.g. SPR, BLI, ELISA, MSD, flow cytometry)
- Plan and coordinate with in vitro/in vivo colleagues to meet program needs
- Manage CROs to ensure timely production of high-quality antibodies and proteins
- Scout, source, and adapt external antibody reagents for Arda’s internal use
- Stay current with emerging protein engineering and characterization technologies; help implement new tools and workflows
- Mentor junior team members and contribute to a culture of scientific rigor and collaboration
Qualifications
- PhD in Biochemistry, Biophysics, Protein Science, Structural Biology, or a related field
- ≥4 years of industry experience in biologics drug discovery
- Extensive experience engineering and characterizing antibodies, immune cell engaging bispecifics, and ADCs
- Expertise in biologics optimization strategies (e.g., Fc engineering, linker-payload design, format selection)
- Proficiency in analytical and functional assays (e.g., SPR, BLI, HPLC, ELISA, MSD, flow cytometry)
- Solid cell and molecular biology skills (cell culture, stable cell line generation, construct design) are a plus
- Strong communication skills and ability to collaborate across disciplines and with external partners
We are committed to building a diverse and inclusive team and encourage candidates from all backgrounds to apply. Join us and help pioneer a new era of precision therapies that change the course of chronic disease.
