(VP) Senior Director Biologics Drug Discovery

insitroOnsite

Job Functions1. Project Team Leader2. Subject Expert3. Biologics Therapeutics Capabilities Builder4. CrossFunctional Driver5. Protein Sciences and Structural Biology Manager

Job Requirements1. PhD in biochemistry, chemistry or cell biology2. 10+ years of industry experience in drug discovery3. 5+ years of direct experience in biologics drug design4. Deep understanding of the biotherapeutic drug discovery process5. Demonstrated track record of leadership advancing biologics projects through different stages of drug discovery and earlystage process and clinical development6. Significant experience in enabling programs with protein reagents and structural biology7. Proven leadership capabilities in crossfunctional teams as a project team leader8. Firsthand experience in using CROs and industry partner for biologics drug discovery9. Track record of innovation and impact on projects through peerreviewed publication and/or patent applications10. Excellent written and verbal communication skills across multifunctional teams

Skills1. PhD in biochemistry, chemistry or cell biology2. 10+ years of industry experience in drug discovery3. 5+ years of direct experience in biologics drug design4. Deep understanding of the biotherapeutic drug discovery process5. Demonstrated track record of leadership advancing biologics projects through different stages of drug discovery and earlystage process and clinical development6. Significant experience in enabling programs with protein reagents and structural biology7. Proven leadership capabilities in crossfunctional teams as a project team leader8. Firsthand experience in using CROs and industry partner for biologics drug discovery9. Track record of innovation and impact on projects through peerreviewed publication and/or patent applications10. Excellent written and verbal communication skills across multifunctional teams1. Intellectual curiosity to push the boundaries of drug discovery2. Openmindedness and willingness to learn new approaches3. Strong collaboration and teamwork skills4. Ability to work in a fastpaced environment with multiple priorities5. Adaptability and flexibility in a dynamic organization

The Opportunity

The heart of insitro's strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and modality independent drug discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we have put together an incredible team of highly talented drug discovery scientists who want to make a difference to these significant problems. In this key role, you will build and lead the Biologics Therapeutics capabilities at insitro within the Drug Discovery department.You will be joining a well funded AI biotech that has established a pipeline of therapeutic candidates but yet is very much in formation, providing many opportunities for significant impact.

You will work closely with a very talented team of Data and Machine Learning scientists, TA biologists and a growing CMC organization, learn a broad range of skills, and help shape insitro's culture, strategic direction, and outcomes. You will report to the Chief Scientific Officer and can be either onsite (3 days per week) in our South San Francisco office or hybrid (~1 week per month) in our office. Additional travel may be needed to relevant medical and translational science conferences and health authorities.Join us, and help make a difference to patients!

Responsibilities

Guide therapeutic biologics efforts in projects as project team leader and subject expert
Build insitro's biologic therapeutic capabilities through extensive CRO and/or industry collaborations
Work cross-functionally to drive biologics projects through different stage gates towards clinical development candidates
Deeply engage cross-functionally to evaluate the suitability of new targets for prosecution by the biologics modality
Evolve and manage a Protein Sciences and Structural Biology team that can enable discovery biology and both large and small molecular modalities
Partner with Business Development and External R&D to evaluate new biotherapeutics technologies

About You

PhD in biochemistry, chemistry or cell biology with 10+ years of industry experience in drug discovery, and with 5+ years of direct experience in biologics drug design
Deep understanding of the biotherapeutic drug discovery process
Demonstrated track record of leadership advancing biologics projects through different stages of drug discovery and early-stage process and clinical development
Significant experience in enabling programs with protein reagents and structural biology
Proven leadership capabilities in cross-functional teams as a project team leader
First hand experience in using CROs and industry partner for biologics drug discovery
Experience in or exposure to computational approaches across the biologics design and bioprocess value chain
Track record of innovation and impact on projects through peer-reviewed publication and/or patent applications
Excellent written and verbal communication skills across multi-functional teams
Intellectual curiosity to push the boundaries of drug discovery

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $247,000 - $316,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.In addition, insitro also provides our employees:

401(k) plan with employer matching for contributions
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
Quarterly budget for books and online courses for self-development
Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
New hire stipend for home office setup
Monthly cell phone & internet stipend
Access to free onsite baristas and cafe with daily lunch and breakfast for employees who are either onsite or hybrid
Access to free onsite fitness center for employees who are either onsite or hybrid
Access to a free commuter bus and ferry network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices.

All candidates can expect equitable treatment, respect, and fairness throughout the interview process.#LI-HybridPlease be aware of recruitment scams: we never request payments, all recruitment communications are from

@insitro.com

, and if in doubt, contact us at info@insitro.com.

About insitro

insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy.

insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com.

Life at insitro

insitro is a data-driven drug discovery and development company that leverages machine learning and high-throughput biology to transform the way medicines are created to help patients. At insitro, we are rethinking the entire drug discovery process, from the perspective of machine learning, human genetics, and high-throughput, quantitative biology. Over the past five decades, we have seen the development of new medicines becoming increasingly more difficult and expensive, leaving many patients with significant unmet need. Weￃﾢ￢ﾂﾬ￢ﾄﾢre embarking on a new approach to drug development ￃﾢ￢ﾂﾬ￢ﾀﾜ one that leverages machine learning and unique in vitro strategies for modeling disease state and designing new therapeutic interventions. We aim to eliminate key bottlenecks in traditional drug discovery, so we can help more people sooner and at a much lower cost to the patient and the healthcare industry. We believe that by harnessing the power of technology to interrogate and measure human biology, we can have a major impact on many diseases. We invest heavily in cutting edge bioengineering technologies to enable the construction of large-scale, high-quality data sets that are designed specifically to drive machine learning methods. Our first application is to use human genetics, functional genomics, and machine learning to build a new generation of in vitro human cell-derived disease models whose response to perturbation is designed to be predictive of human clinical outcomes. This cannot be done without great people. We are bringing together an outstanding team of people whose expertise spans multiple disciplines - life sciences, machine learning, human genetics, engineering, and drug discovery - and building a unique culture where people from diverse backgrounds work as a single team towards a common goal. We offer opportunities to collaborative people with expertise in life science and computational science. Join us to help bring better health to more people, faster and cheaper.

Thrive Here & What We Value1. Inclusive, growth-oriented environment supported by equitable company and team practices2. Open, flexible vacation policy3. Paid parental leave4. Quarterly budget for books and online courses for self-development5. Monthly cell phone & internet stipend6. Access to free onsite baristas and cafe with daily lunch and breakfast7. Access to free onsite fitness center8. Commuter benefits9. Equal opportunity employer1e. Commitment to diversity, equity, and inclusion