We are seeking a highly motivated and qualified individual to join our
Exploratory Discovery
Department as a Research Associate I and work as part of a team to drive success. Ideal candidates will be self-motivated, independent, committed to the generation of high-quality data within a fast-paced and innovative research team.
The Research Associate I will support the discovery and development of novel delivery strategies to enable extrahepatic siRNA delivery. This position offers an exciting opportunity to contribute to RNA-based drug discovery programs across multiple therapeutic areas. The ideal candidate will help drive innovative approaches that enhance the efficacy, specificity, and safety of siRNA therapeutics for a wide range of complex disease indications.
Essential Responsibilities:
- Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
- Conduct in vivo studies in compliance with IACUC protocols and internal SOPs.
- Perform routine rodent procedures including dosing via various routes (IV, SC, PO, IP, IVT), physiological monitoring, blood collection (e.g., cheek puncture, tail vein), necropsy and tissue collection
- Assist project leads with study scheduling, preparation of study protocols and materials
- Manage genetically engineered mouse colonies. Responsibilities include breeding setup and maintenance, plug checking, pregnancy confirmation, weaning, animal identification (e.g., ear punching or tagging), and genotyping via PCR
- Conduct pharmacokinetic (PK) and pharmacodynamic (PD) evaluations using ex vivo tissue and blood samples
- Accurately document experimental data and maintain well-organized lab notebooks and electronic records.
- Maintain and calibrate lab equipment and ensure proper functioning to support study execution
- Establish and maintain excellent working relationships with critical collaborative partners throughout the company.
- Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
- Maintain updated and well-organized lab notebooks.
- Execute daily laboratory operations with an approach designed to minimize risks and hazard waste streams.
- Maintain all appropriate corporate standards for facility safety and hazardous material management.
- Other duties as assigned.
Essential Physical Characteristics:
Reasonable accommodation(s) may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.
On-Site Protocol:
Physical presence at the ADARx Pharmaceuticals worksite is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.Qualifications:
- BA, BS or Msc degree in Biological Sciences or a related field with a minimum of 2 years of hands-on experience in in vivo pharmacology within an academic, biotech, pharmaceutical, or CRO setting.
- Demonstrated proficiency in rodent handling and dosing techniques (IV, SC, PO, IP, IVT).
- Experience in blood collection, physiological monitoring, necropsy, and tissue harvesting.
- Familiarity with IACUC protocol development and compliance is strongly preferred
- Experience with ex vivo assays such as ELISA, western blot, RT-qPCR, and cell culture.
- Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
- Strong problem-solving skills and a proactive attitude towards exploring new approaches.
- Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role.
- Willingness to work occasional weekends based on study needs.
- Proficiency working with Microsoft Office Suite Products.
Preferred Qualifications:
- Prior experience in biotech/pharmaceutical industry a plus.
- Prior experience working with genetically engineered mouse models is desirable.
Required Key Attributes:
- Must be able to work independently as well in cross-functional team settings with supervision as needed.
- Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
- Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.
Compensation:
- This is a full-time position, Monday-Friday, occasional overtime.
- Pay is commensurate with experience.
- Equity-based compensation
- Performance-based bonuses
- 401(k) with Company Match
- Medical, Dental, Vision
- Flexible Spending Account
- Life Insurance
- Employee Assistance Program
- Employee Discounts
- Gym Membership
- Paid Vacation
- Paid Holidays
- Paid Sick, Jury Duty, Bereavement
Work Authorization:
- United States (Required)
- Background Check
- As a condition of employment, you must successfully complete all post-offer, pre-employment requirements, including but not limited to a background check.
Company Overview:
We are a late-stage clinical biotechnology company dedicated to transforming cutting-edge science into next-generation RNA medicines across a wide range of therapeutic areas. Our goal is to control the expression of specific disease drivers with highly selective RNA targeted therapies, delivering life-changing treatments for patients with urgent unmet medical needs.
ADARx Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.
Disclosure Statement:
- The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.
- Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
- The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual target bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, type and length of experience within the industry, and other job-related factors permitted by law.
- Total Compensation includes base salary; benefits: medical, vision, and dental insurance; life insurance; 401(k) matching program; paid time off; paid holidays; Employee Assistance Program; and other employee benefits. This role may also be eligible for short-term or long-term incentive compensation, including but not limited to cash bonuses.
- Following a conditional offer of employment, satisfactory completion of a background check (including criminal records check) is required prior to beginning employment. Any offer of employment may be rescinded if the background check reveals disqualifying information, and/or it is discovered that the candidate knowingly withheld or falsified information. Failure to satisfactorily complete the background check may affect the continued employment of a current NAI employee who was conditionally offered the position.
60000.00 To 75000.00 (USD) Annually
