Senior Scientist I, Conjugation

Job Description:

Essential Responsibilities:

• Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using novel chemistries and technologies for target drug delivery.
• Evaluate SAR on the conjugates and drive the program by collaborating cross-functionally with the teams.
• Track progress against project timelines, generate regular status updates, and communicate progress to the team. 
• Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audience.
• Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
• Maintain updated and well-organized lab notebooks and batch records.
• Execute daily laboratory operations with an approach designed to minimize risks and hazard waste streams.
• Maintain all appropriate corporate standards for facility safety and hazardous material management.
• Other duties as assigned.

Essential Physical Characteristics:

On-Site Protocol:

• Ph.D. in Chemistry, or related scientific discipline
• 3-5 years bioconjugation-related industrial experience.
• Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Strong problem-solving skills and a proactive attitude towards exploring new approaches.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role.
• In-depth knowledge of modern bioconjugation methods on antibodies (ADC, AOC), proteins, peptides, and other biomolecules.
• Hands-on experience in the analytical characterization of the conjugates with strong analytical mindset. Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX. 
• Proficiency working with Microsoft Office Suite Products.

Preferred Qualifications:

• Team management experience
• Previous experience with RNA/oligonucleotide therapeutics is preferred but not essential.
• A track-record of impacting drug discovery programs through driving projects to key decision points.
• In-depth knowledge of modern organic synthetic methods, purification and analytical techniques as well as medicinal chemistry.

Required Key Attributes:

• Positive attitude and high personal and ethical standards. A strong team player with a passion for science and drug discovery.
• Must be able to work independently as well in cross-functional team settings with supervision as needed.
• Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
• Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.

Compensation:

• This is a full-time position, Monday-Friday, occasional overtime.
• Pay is commensurate with experience.
• Equity-based compensation
• Performance-based bonuses
• 401(k) with Company Match
• Medical, Dental, Vision
• Flexible Spending Account
• Life Insurance
• Employee Assistance Program
• Employee Discounts 
• Paid Vacation
• Paid Holidays
• Paid Sick, Jury Duty, Bereavement

Work Authorization:

• United States (Required)
• Background Check

Company Overview:

ADARx Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Disclosure Statement:

• The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.
• Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
• The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual target bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, type and length of experience within the industry, and other job-related factors permitted by law.
• Total Compensation includes base salary; benefits: medical, vision, and dental insurance; life insurance; 401(k) matching program; paid time off; paid holidays; Employee Assistance Program; and other employee benefits. This role may also be eligible for short-term or long-term incentive compensation, including but not limited to cash bonuses.
• Following a conditional offer of employment, satisfactory completion of a background check (including criminal records check) is required prior to beginning employment. Any offer of employment may be rescinded if the background check reveals disqualifying information, and/or it is discovered that the candidate knowingly withheld or falsified information. Failure to satisfactorily complete the background check may affect the continued employment of a current NAI employee who was conditionally offered the position. 110000.00 To 140000.00 (USD) Annually