Attention recruitment agencies:
All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products.
We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases. Company Differentiators: • Fully integrated clinical-phase company with internal manufacturing• Demonstrated ability to move rapidly from idea to IND• Five candidate products in the clinic and two declared pre-clinical programs• Robust technology and IP foundation, including our TVE and manufacturing platforms• Initial product safety and efficacy data substantiates the value of our platforms• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY
The Executive Medical Director is a key leadership role and will develop, implement, and lead the portfolio strategy and life cycle management planning across indications. The successful candidate will be responsible for leading cross-functional communication and collaboration across the organization to ensure the execution of global medical affairs strategy across all geographic regions ensuring a cohesive approach for the franchise. This role will develop and lead medical affairs activities ensuring partnership within the team (medical strategy, scientific communications and publications) and across all key Medical Affairs functions (Medical Excellence, HEOR, Field Medical, Medical Information) to ensure alignment and one 4DMT approach.
RESPONSIBILITIES:
- Establish and shape medical strategy for entry into new indications and across indications ensuring this fits within the overall company strategy and maintaining cross functional alignment.
- Ensure that strategy is reflected in medical plans and that these deliver on critical identified milestones.
- Provide medical leadership within the Market Preparation Team and provide input for cross functional partners including clinical development and commercial to ensure that there is a strong medical voice represented.
- Demonstrate strategic thinking to translate medical/clinical insights of treatment paradigms into growth opportunities, while driving competitive advantage.
- Act as key scientific reviewer, provide leadership for company sponsored medical affairs research programs and external research, and lead the creation of a robust scientific education plan for healthcare professionals and other stakeholders as well as internal for global medical training, field medical leadership across all regions and HEOR.
- Build external relationship network for existing and new indications to help drive trial enrollment, launch prep, and gain advice.
- Develop and drive data generation strategy, working cross functionally, including gap analysis to evolve product data generation plans and ensure strategy for existing and new indications encompassing a franchise approach.
- Provide key strategic input into publication planning and review, medical backgrounders, FAQ and standard responses, internal training approach, and data dissemination.
- Propose future Medical Strategy team needs to advance programs as they progress.
- Develop full thought leader engagement strategic approach and ensuing plan and provide strategic oversight to the cross functional medical engagement plans.
- Deliver high quality educational presentations internally and externally, as required.
- Ensure a comprehensive and synergistic approach by collaborating across Medical Affairs, Regions, and other functions including Commercial and Development.
QUALIFICATIONS:
Education:
- Medical Doctor (M.D.), Doctor of Osteopathy (D.O.), Doctor of Pharmacy (PharmD), Doctor of Optometry (OD), or equivalent degree with relevant therapeutic specialty in the pharmaceutical industry, community, academic or hospital environment required.
Experience:
- 7+ years of clinical trial experience in the pharmaceutical industry, academia, or equivalent. Deep therapeutic area expertise strongly preferred.
- 2+ years must have worked on clinical trials within a pharmaceutical company
- Ability to prioritize across, and help others effectively lead, several complex clinical research programs.
- Proven leadership skills and ability to bring out the best in others on a cross-functional global team. Must be able to lead and manage through influence.
- Prior experience as a direct or matrixed manager, with a demonstrated track record of training and development of junior-level staff, using best judgment to assure that they work with an appropriate level of autonomy.
- Ability to interact externally and internally to support a global scientific and business strategy.
- Extensive knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in development of clinical strategy and the design of study protocols.
- Must possess excellent oral and written English communication skills.
- Ability to exercise judgment and address complex problems and create solutions across multiple projects.
Base salary compensation range: $333,000 - $422,0004DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
